Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Selman, M
Right arrow Articles by Stricklin, G
Right arrow Search for Related Content
PubMed
Right arrow Articles by Selman, M
Right arrow Articles by Stricklin, G

Chest, Vol 100, 151-155, Copyright © 1991 by American College of Chest Physicians

ARTICLES

Collagenase and collagenase inhibitors in bronchoalveolar lavage fluids

M Selman, A Pardo, N Barquin, R Sansores, R Ramirez, C Ramos, M Montano and G Stricklin
Instituto Nacional de Enfermedades Respiratorias, Facultad de Ciencias, Universidad Nacional Autonoma de Mexico.

Collagenase, collagenolytic activity and tissue inhibitor of metalloproteinases were evaluated in bronchoalveolar lavage from 25 patients with hypersensitivity pneumonitis and four control subjects. Patients were followed between two and three years, after which they were classified as "healed," "improved," or "worsened." In control samples, immunoreactive collagenase was not detected. The enzyme was present in four of seven patients who healed, six of ten patients who improved, and four of eight patients who worsened. There was no relationship between the presence or absence of BAL collagenase or its concentration and the evolution of the disease. Latent collagenolytic activity was detected only in 5 of the 14 patients who displayed immunoreactive collagenase. Regarding collagenase inhibitor, TIMP was present in BAL fluid from all patients and normal subjects. Although the highest values were found in two cases who healed or improved, there was not a statistically significant difference among the three groups of patients, neither between patients nor control subjects. These findings suggest that at least in HP, the presence of collagenase, collagenolytic activity, or TIMP in BAL fluid is not associated with the prognosis of the disease.


This article has been cited by other articles:


Home page
 ChestHome page
M. Montano, C. Beccerril, V. Ruiz, C. Ramos, R. H. Sansores, and G. Gonzalez-Avila
Matrix Metalloproteinases Activity in COPD Associated With Wood Smoke
Chest, February 1, 2004; 125(2): 466 - 472.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. CAMARENA, A. JUAREZ, M. MEJIA, A. ESTRADA, G. CARRILLO, R. FALFAN, J. ZUNIGA, C. NAVARRO, J. GRANADOS, and M. SELMAN
Major Histocompatibility Complex and Tumor Necrosis Factor-{alpha} Polymorphisms in Pigeon Breeder's Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1528 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Segura-Valdez, A. Pardo, M. Gaxiola, B. D. Uhal, C. Becerril, and M. Selman
Upregulation of Gelatinases A and B, Collagenases 1 and 2, and Increased Parenchymal Cell Death in COPD
Chest, March 1, 2000; 117(3): 684 - 694.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1991 by the American College of Chest Physicians.