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Chest, Vol 100, 201-206, Copyright © 1991 by American College of Chest Physicians

ARTICLES

Coronary thrombolysis with recombinant tissue plasminogen activator. Intracoronary vs intravenous administration

SA Gu, J Ducas, K Wolfe, JN Patton and RM Prewitt
Section of Cardiology, University of Manitoba, Winnipeg, Canada.

We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of recombinant tissue plasminogen activator (rtPA) administered intravenously and administered directly into the coronary circulation. A control group did not receive rtPA. Compared with controls, both rtPA regimens induced coronary thrombolysis. However, compared with intravenous administration, rate and extent of coronary thrombolysis were increased with intracoronary administration. Most likely, the enhanced thrombolysis with intracoronary administration is explained by an increase in delivery of the drug to the thrombus.




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Copyright © 1991 by the American College of Chest Physicians.