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(Chest. 1991;100:173S-175S.)
© 1991 American College of Chest Physicians

Macrophages in Acute and Chronic Inflammation

Clemens Sorg Ph.D.1

1 The Institute of Experimental Dermatology, University of Münster, Münster, Germany.

Acute inflammatory reactions are dynamic processes that involve the sequential appearance of different macrophage populations. The association of the 27E10 phenotype with acute inflammatory reactions and the RM3/1 phenotype with the downregulatory stage of the inflammatory reaction opens new perspectives with regard to diagnosis and treatment of diseases. The dominating role of macrophages in most inflammatory lesions also suggests that the macrophage system could play a central role in a variety of chronic inflammatory diseases. Thus, it would be logical to focus on this cellular system not only in the treatment of inflammatory diseases but also in their prevention.






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Copyright © 1991 by the American College of Chest Physicians.