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Chest, Vol 100, 1277-1280, Copyright © 1991 by American College of Chest Physicians

ARTICLES

Human alveolar macrophages of anergic patients with lung cancer lack the responsiveness to recombinant interferon gamma

H Kawatsu, Y Hasegawa, E Takagi and K Shimokata
First Department of Medicine, Nagoya University School of Medicine, Japan.

We studied the effect of recombinant interferon gamma (rIFN-gamma) on the phagocytic and bactericidal actions in human alveolar macrophages (AM) of patients with pulmonary tuberculosis and lung cancer. Treatment with 100 or 1,000 U/ml of rIFN-gamma for 24 hours resulted in an increased percentage of AM ingesting bacillus Calmette-Guerin (BCG) and an increased number of ingested BCG in individual AM in tuberculin- positive patients with lung cancer and pulmonary tuberculosis. The rIFN- gamma treatment also showed increased killing activity of AM in tuberculin-positive patients. However, rIFN-gamma treatment of AM in tuberculin-negative anergic patients with lung cancer did not induce the increase of phagocytic and killing activities against BCG. These results suggest that responsiveness and activation of AM to rIFN-gamma are inhibited in the anergic environment.




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Copyright © 1991 by the American College of Chest Physicians.