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Chest, Vol 101, 102-104, Copyright © 1992 by American College of Chest Physicians

ARTICLES

Acute pulmonary edema induced by overdosage of phenothiazines

C Li and WB Gefter
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.

Three schizophrenic adults with previous histories of using phenothiazine derivatives developed acute pulmonary edema after taking large amounts of these drugs. The clinical manifestations included coma (three), hypothermia (two), tachycardia (two), miosis (two) and hypotension (one). All three patients underwent gastric lavage and were treated supportively. The fulminant pulmonary edema in the three cases resolved within 18 to 40 h. The etiology of pulmonary edema following overdosage of phenothiazines remains unknown. The authors hypothesize that the most likely pathogenesis is a drug-induced neurogenic pulmonary edema resulting from a disturbance of hypothalamic function.




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Copyright © 1992 by the American College of Chest Physicians.