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Chest, Vol 101, 922-925, Copyright © 1992 by American College of Chest Physicians

ARTICLES

Angiotensin-converting enzyme inhibitors in patients with bronchial responsiveness and asthma

J Kaufman, S Schmitt, J Barnard and W Busse
Medical College of Wisconsin, Milwaukee.

Twenty-one subjects with known bronchial hyperreactivity were prospectively randomized in double-blind fashion to receive one of two angiotensin-converting enzyme inhibitors (ACE-I), enalapril or spirapril, for three weeks. Spirometry and methacholine provocation were performed prior to, during, and following ACE-I usage. Three of 21 subjects developed a nonproductive cough. However, only one subject wheezed slightly. Spirometry and bronchial reactivity (PD20) were unchanged throughout the study.


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H Lunde, T Hedner, O Samuelsson, J Lotvall, L Andren, L Lindhom, and B E Wilholm
Dyspnoea, asthma, and bronchospasm in relation to treatment with angiotensin converting enzyme inhibitors
BMJ, January 1, 1994; 308(6920): 18 - 18.
[Abstract] [Full Text]


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Copyright © 1992 by the American College of Chest Physicians.