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Chest, Vol 101, 996-999, Copyright © 1992 by American College of Chest Physicians

ARTICLES

Inhibition of interferon gamma production by peripheral blood mononuclear leukocytes of patients with sarcoidosis. Pathogenic implications

G Bertran, E Arzt, E Resnik, C Mosca and V Nahmod
Departamento de Sustancias Vasoactivas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

Interferon gamma (IFN-gamma) production by stimulated peripheral mononuclear leukocytes of 30 patients with sarcoidosis was studied. A significant inhibition (64 percent, 5 to 330 IU/ml vs normal individuals = 1,000 +/- 250 IU/ml) in the IFN-gamma synthesis was found. The inhibition is due to a defect in the circulating monocytes and not in the peripheral T lymphocytes of these patients. This defect in the peripheral IFN-gamma production could be involved in the pathogenesis of this disease.


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L. S. Newman, C. S. Rose, and L. A. Maier
Sarcoidosis
N. Engl. J. Med., April 24, 1997; 336(17): 1224 - 1234.
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