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1 Professor of Cardiology., The National Heart and Lung Institute, London, England.
2 The National Heart and Lung Institute, London, England.
The cause of symptoms in heart failure is still unknown. A major issue at the present time is whether the reduction in skeletal muscle mass that accompanies heart failure is the cause of an altered response to exercise and whether the patient perceives the changed pattern of signals in such a way as to give rise to the symptoms described as breathlessness and fatigue.
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