The Relationship of Viral Respiratory Infections and Asthma

¹ The University of Wisconsin Medical School, Madison.

There are a number of other mechanisms which contribute to virus-induced asthma, including beta-adrenergic dysfunction, epithelial injury, and potentiation of neurogenic inflammation. However, all the mechanisms involved in the development of airway hyperresponsiveness, airway obstruction, and recurrent wheezing with viral respiratory infections have yet to be fully appreciated. Nonetheless, current evidence indicates that viruses, or products of virus-infected cells, influence the inflammatory property and potential of many cells. Precisely how these virus-effects translate into increased airway injury, responsiveness, and obstruction will require further work. As the mechanisms of these interactions are established, so will improved understanding of asthma pathogenesis and treatment.