Clinical Features of BOOP in Japan

¹ The Second Department of Internal Medicine, Nagoya City University
² Chest Disease Research Institute, Kyoto University
³ Chief, Research Committees on Interstitial Pulmonary Diseases, Ministry of Health and Welfare of Japan., Tokyo Teishin Hospital
⁴ Chief, Research Committees on Diffuse Pulmonary Disease, Ministry of Health and Welfare of Japan., The Third Department of Internal Medicine, Iwate Medical University, Tokyo, Japan.

The clinical features derived from 29 BOOP cases diagnosed by open lung biopsy specimen in Japan are summarized as follows: (1) 70% of BOOP cases in Japan were idiopathic, while 20% were associated with collagen vascular disease. (2) BOOP could be classified into 2 major types (type 1 and type 2). Some that could not be classified into those 2 types were unclassified. Type 1 (wandering type) showed bilateral multiple patchy densities that wandered throughout the pulmonary fields. Thirteen cases were classified as type 1. Type 2 (not wandering type) showed bilateral basilar micronodular densities. Eight cases were classified as type 2. (3) Type 1 more frequently showed fever, leukocytosis, accelerated ESR, and positive CRP than type 2, indicating stronger inflammatory processes. (4) Two of the 29 patients with BOOP died. Those 2 patients belonged to the idiopathic group. One patient died of BOOP and the other patient died of fungal infection probably induced by corticosteroid therapy. [See Table 7 and 8 in source pdf].