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Chest, Vol 102, 556-559, Copyright © 1992 by American College of Chest Physicians

ARTICLES

Increased urinary loss of uric acid in adults with acute respiratory failure requiring mechanical ventilation

EF Christensen, J Jacobsen, E Anker-Moller, P Schultz and N Spangsberg
Department of Anesthesiology, Arhus Amtssygehus, Denmark.

INTRODUCTION: The purpose of this study was to test a hypothesis of increased urinary excretion of uric acid as an indicator of adenosine triphosphate (ATP) degradation in adult patients with acute respiratory failure, and to look for a correlation to the clinical outcome. STUDY DESIGN: Prospectively 31 patients with acute respiratory failure were studied. The patients were divided into two groups according to the clinical outcome: the need for solely supplemental oxygen (group 1), death or mechanical ventilation (group 2). METHODS: Uric acid was determined by spectrophotometry. RESULTS: Mean uric acid excretion was 39 mumol/kg (range, 7 to 92 mumol/kg) body weight/per 24 h in group 1 (16 patients) compared with 65 mumol/kg/24 h (range, 8 to 253 mumol/kg/24 h) in group 2 (13 patients were mechanically ventilated, and two patients died). The difference was highly significant (p less than 0.0001). CONCLUSION: Increased amount of urinary uric acid was related to the severity of acute respiratory failure in adults.




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Copyright © 1992 by the American College of Chest Physicians.