Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horak, D.
Right arrow Articles by Forman, S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Horak, D.
Right arrow Articles by Forman, S.

Chest, Vol 102, 1484-1490, Copyright © 1992 by American College of Chest Physicians

ARTICLES

Pretransplant pulmonary function predicts cytomegalovirus-associated interstitial pneumonia following bone marrow transplantation

DA Horak, GM Schmidt, JA Zaia, JC Niland, C Ahn and SJ Forman
Department of Respiratory Diseases, City of Hope National Medical Center, Duarte, CA 91010.

STUDY OBJECTIVE: To determine the value of pulmonary function tests (PFTs) in predicting the development of human cytomegalovirus (CMV)- associated interstitial pneumonia (IP) in allogeneic bone marrow transplant (BMT) recipients. DESIGN: Nonrandomized, prospective, open- trial study. SETTING: Tertiary referral medical center. PATIENTS: 66 evaluable CMV-seropositive patients with hematologic malignancies who were undergoing allogeneic BMT. INTERVENTION: FEV1, FVC, FEV1/FVC, TLC, Dcoc/VA, PaO2, and P(A-a)O2 were measured on days -13, +33, and +44 following BMT. CMV-IP was diagnosed when typical roentgenographic findings developed with confirmatory positive bronchoalveolar lavage (BAL) using standard cytologic and/or rapid culture techniques. MEASUREMENT AND MAIN RESULTS: Univariate logistic regression analysis to predict the development of CMV-IP revealed significant associations with the day -13 and +33 percent predicted FEV1, FVC, and TLC (p < 0.01) but no associations with other PFT parameters or with changes in these parameters. Stepwise logistic regression analysis demonstrated that only BAL positivity for CMV (odds ratio 14.8; p = 0.0002) and day - 13 percent predicted FEV1 (odds ratio 0.92; p = 0.0004) were significant independent predictors of CMV-IP. CONCLUSION: Pretransplant lung function is a previously unrecognized strong predictor and risk factor for the subsequent development of CMV-IP in BMT recipients.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Parimon, D. K. Madtes, D. H. Au, J. G. Clark, and J. W. Chien
Pretransplant Lung Function, Respiratory Failure, and Mortality after Stem Cell Transplantation
Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 384 - 390.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. Afessa
Pretransplant Pulmonary Evaluation of the Blood and Marrow Transplant Recipient
Chest, July 1, 2005; 128(1): 8 - 10.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. M. Kotloff, V. N. Ahya, and S. W. Crawford
Pulmonary Complications of Solid Organ and Hematopoietic Stem Cell Transplantation
Am. J. Respir. Crit. Care Med., July 1, 2004; 170(1): 22 - 48.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A T Whittle, M Davis, C L Shovlin, P S Ganly, C Haslett, and A P Greening
Alveolar macrophage activity and the pulmonary complications of haematopoietic stem cell transplantation
Thorax, December 1, 2001; 56(12): 941 - 946.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by the American College of Chest Physicians.