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Chest, Vol 102, 1764-1766, Copyright © 1992 by American College of Chest Physicians

ARTICLES

Efficacy of engineering controls in reducing occupational exposure to aerosolized pentamidine

MA McDiarmid, J Schaefer, CL Richard, RE Chaisson and BS Tepper
Johns Hopkins Medical Institutions, Baltimore.

Aerosolized pentamidine administration may pose potential risks to health care workers exposed to fugitive drug and to infectious respiratory pathogens (eg, tuberculosis) generated by pentamidine- induced cough. Classic infection control methods may be applied to this problem, although the effectiveness of these measures in mitigating environmental pentamidine exposure is unknown. Lack of data fully characterizing pentamidine's mechanism of action or potential mutagenicity, carcinogenicity, or teratogenicity raises concern and suggests worker exposed and environmental contamination be minimized. We report herein on the efficacy of an aerosol containment hood in containing fugitive pentamidine aerosol during administration.




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Copyright © 1992 by the American College of Chest Physicians.