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Chest, Vol 102, 1794-1799, Copyright © 1992 by American College of Chest Physicians

ARTICLES

Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage

E Grebski, T Hess, G Hold, R Speich and E Russi
Department of Internal Medicine, University Hospital, Zurich, Switzerland.

STUDY OBJECTIVE: Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN: One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN RESULTS: The highest values for the hemosiderin score (HS) were found in patients with active alveolar hemorrhage and patients who had undergone heart transplantation for congestive heart failure. Compared to a control population, patients with Pneumocystis carinii pneumonia or invasive aspergillosis had a higher HS than patients with bacterial pneumonia or mycobacterial lung infection. High or intermediate values for HS were more often found in patients with a low than in those with a normal platelet count. CONCLUSIONS: The differential diagnostic conclusions which can be based on an HS are limited.


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