Chest, Vol 103, 479-483, Copyright © 1993 by American College of Chest Physicians

ARTICLES

Release of tumor necrosis factor-alpha from human alveolar macrophages is decreased in smokers

E Yamaguchi, A Itoh, K Furuya, H Miyamoto, S Abe and Y Kawakami
First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.

It is known that smoking affects the development and maintenance of certain types of granulomatous lung diseases. To explore this mechanism(s), we measured tumor necrosis factor (TNF)-alpha concentrations in the culture supernatants of lipopolysaccharide (LPS)- stimulated alveolar macrophages (AMs) in 13 healthy nonsmokers, 13 healthy smokers, 13 nonsmoking sarcoid patients, and 16 smoking sarcoid patients. We found that the capacity of smokers' AMs to release TNF- alpha was significantly decreased both in the normal and sarcoid groups. We also confirmed the previous observation that there was an exaggerated TNF release in patients with pulmonary sarcoidosis. These results indicate a significant role of TNF-alpha in the pathogenetic mechanisms of pulmonary sarcoidosis and suggest the possible involvement of TNF in the mechanisms by which smoking modulates local immune phenomena.

This article has been cited by other articles:

				Y. Zhou, E. Yamaguchi, Y. Fukui, S. Konno, Y. Maeda, K. Kimata, and M. Nishimura Enhanced Expression of Interleukin-18 Receptor {alpha} Chain by CD4+ T Cells in Sarcoidosis Chest, October 1, 2005; 128(4): 2497 - 2503. [Abstract] [Full Text] [PDF]

				K. Matsunaga, T. W. Klein, H. Friedman, and Y. Yamamoto Epigallocatechin Gallate, a Potential Immunomodulatory Agent of Tea Components, Diminishes Cigarette Smoke Condensate-Induced Suppression of Anti-Legionella pneumophila Activity and Cytokine Responses of Alveolar Macrophages Clin. Vaccine Immunol., July 1, 2002; 9(4): 864 - 871. [Abstract] [Full Text] [PDF]

				H Visser, K Vos, E Zanelli, W Verduyn, G M T. Schreuder, I Speyer, F C Breedveld, and J M W Hazes Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors Ann Rheum Dis, June 1, 2002; 61(6): 499 - 504. [Abstract] [Full Text] [PDF]

				M Tanino, T Betsuyaku, K Takeyabu, Y Tanino, E Yamaguchi, K Miyamoto, and M Nishimura Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema Thorax, May 1, 2002; 57(5): 405 - 411. [Abstract] [Full Text] [PDF]

				L. A. MAIER, R. T. SAWYER, R. A. BAUER, L. A. KITTLE, P. LYMPANY, D. MCGRATH, R. DUBOIS, E. DANILOFF, C. S. ROSE, and L. S. NEWMAN High Beryllium-stimulated TNF-alpha Is Associated with the -308 TNF-alpha Promoter Polymorphism and with Clinical Severity in Chronic Beryllium Disease Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1192 - 1199. [Abstract] [Full Text] [PDF]

				E. Yamaguchi, A. Itoh, N. Hizawa, and Y. Kawakami The Gene Polymorphism of Tumor Necrosis Factor-{beta}, But Not That of Tumor Necrosis Factor-{{alpha}}, Is Associated With the Prognosis of Sarcoidosis Chest, March 1, 2001; 119(3): 753 - 761. [Abstract] [Full Text] [PDF]

				K. Shigehara, N. Shijubo, M. Ohmichi, R. Takahashi, S.-i. Kon, H. Okamura, M. Kurimoto, Y. Hiraga, T. Tatsuno, S. Abe, et al. IL-12 and IL-18 Are Increased and Stimulate IFN-{{gamma}} Production in Sarcoid Lungs J. Immunol., January 1, 2001; 166(1): 642 - 649. [Abstract] [Full Text] [PDF]

				N. Kodama, E. Yamaguchi, N. Hizawa, K. Furuya, J.-i. Kojima, M. Oguri, T. Takahashi, and Y. Kawakami Expression of RANTES by Bronchoalveolar Lavage Cells in Nonsmoking Patients with Interstitial Lung Diseases Am. J. Respir. Cell Mol. Biol., April 1, 1998; 18(4): 526 - 531. [Abstract] [Full Text]