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Chest, Vol 103, 1899-1901, Copyright © 1993 by American College of Chest Physicians

ARTICLES

Severe ischemic injury to the proximal airway following lung transplantation. Immediate and long-term effects on bronchial cartilage. Multi-Organ Transplant Group

AE Frost, CA Keller and PT Cagle
Department of Medicine, Methodist Hospital, Baylor College of Medicine, Houston.

Ischemia due to interruption of the bronchial circulation has been recognized as a cause of immediate postoperative anastomotic dehiscence in lung and heart-lung transplant recipients. Since patients do not ordinarily survive such major ischemic insults, the long-term effects of airway ischemia and the differentiation of these effects from those of transplant rejection and infection have not been clearly defined. We describe a patient who suffered extensive airway ischemia, necrosis, and subsequent diffuse airway stenosis. Loss of the bronchial circulation with variable ischemia may be a major cause of late airway abnormality responsible for significant morbidity and mortality in transplant recipients.




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Copyright © 1993 by the American College of Chest Physicians.