Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cormier, Y
Right arrow Articles by Begin, R
Right arrow Search for Related Content
PubMed
Right arrow Articles by Cormier, Y
Right arrow Articles by Begin, R

Chest, Vol 104, 1038-1042, Copyright © 1993 by American College of Chest Physicians

ARTICLES

Fibrogenic activities in bronchoalveolar lavage fluid of farmer's lung

Y Cormier, M Laviolette, A Cantin, GM Tremblay and R Begin
Centre de Pneumologie de l'Hopital Laval, Universite Laval, Quebec, Canada.

Hyaluronic acid (HA), type III procollagen, fibronectin, and fibroblast growth factors (FGF) were measured in 43 bronchoalveolar lavage fluid (BALF) specimens obtained from 38 patients with farmer's lung (FL) and in BALF of 9 nonexposed normal control subjects. Bronchoalveolar lavage was done in 21 farmers with acute FL (acute) and in 22 with a history of previous FL (Ex) who were still in daily contact with dairy barns. All farmers from the acute and Ex groups had a lymphocytic alveolitis, respectively, 62.7 (3.5) percent (mean [SEM]) and 48.1 (4.3) percent. Hyaluronic acid, type III procollagen, fibronectin, and FGF were all highly increased in acute disease. These substances were also increased in the BALF of subjects of the Ex group who had no clinical symptoms or signs of acute disease at the time of lavage, but were actively farming. The increase in type III procollagen, however, was less in this group than in the subjects with acute disease. These observations suggest that the fibrosing activities and potentialities of the allergic alveolitis of FL are fully expressed at the time of clinical presentation and also in the subclinical phase of the disease in susceptible farmers who remain exposed after an initial acute phase of the disease.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
J. N. Fink, H. G. Ortega, H. Y. Reynolds, Y. F. Cormier, L. L. Fan, T. J. Franks, K. Kreiss, S. Kunkel, D. Lynch, S. Quirce, et al.
Needs and Opportunities for Research in Hypersensitivity Pneumonitis
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 792 - 798.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. C. Savani, G. Hou, P. Liu, C. Wang, E. Simons, P. C. Grimm, R. Stern, A. H. Greenberg, H. M. DeLisser, and N. Khalil
A Role for Hyaluronan in Macrophage Accumulation and Collagen Deposition after Bleomycin-Induced Lung Injury
Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 475 - 484.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Schenker
Respiratory Health Hazards in Agriculture
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(2007): S1 - S76.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by the American College of Chest Physicians.