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Chest, Vol 105, 1266-1268, Copyright © 1994 by American College of Chest Physicians

ARTICLES

Can heparin cause adult respiratory distress syndrome by a similar mechanism as heparin-associated thrombocytopenia?

PJ Asimacopoulos, I Athanasiadis, JJ McCarthy, RJ Shade and RB Teague
Department of Surgery, Baylor College of Medicine, Houston.

A 62-year-old woman who underwent an aortic valve replacement for severe aortic valve stenosis developed postoperative thrombocytopenia and adult respiratory distress syndrome, simultaneously. Both complications resolved promptly after discontinuing heparin therapy. The presence of a heparin-related antiplatelet antibody was detected by in vitro testing. The time course of clinical events suggests the possibility of a heparin-induced, immune-mediated injury to both the pulmonary vascular endothelium and the platelet membrane as an underlying pathophysiologic mechanism.


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 Ann. Thorac. Surg.Home page
F. Follis and C. A. Schmidt
Cardiopulmonary bypass in patients with heparin-induced thrombocytopenia and thrombosis
Ann. Thorac. Surg., December 1, 2000; 70(6): 2173 - 2181.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the American College of Chest Physicians.