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Chest, Vol 105, 1335-1337, Copyright © 1994 by American College of Chest Physicians


ARTICLES

Normalization of CD4+ T-lymphocyte depletion in patients without HIV infection treated for tuberculosis

GS Turett and EE Telzak
Division of Infectious Diseases, Bronx-Lebanon Hospital Center, NY.

A decrease in the number of circulating CD4+ T-lymphocytes occurs in subjects infected with the human immunodeficiency virus (HIV). In those without HIV infection, depletion of T-lymphocytes in general and CD4+ cells in particular has been reported in association with many underlying conditions, including tuberculosis. A low CD4+ T-lymphocyte count at the time of diagnosis of tuberculosis does not clarify whether the low count is a predisposing factor for or a consequence of the disease. Our patients without HIV infection but with tuberculosis and CD4+ T-lymphocyte depletion on presentation normalized their CD4+ cell counts with tuberculosis treatment. This normalization strongly suggests that tuberculosis is a reversible cause of CD4+ lymphocytopenia.


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