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Chest, Vol 105, 1406-1410, Copyright © 1994 by American College of Chest Physicians

ARTICLES

Replacement therapy for hereditary alpha1-antitrypsin deficiency. A program for long-term administration

AF Barker, F Siemsen, D Pasley, R D'Silva and AS Buist
Department of Pulmonary and Critical Care Medicine, Oregon Health Sciences University, Portland.

This retrospective chart review describes the efficacy and safety of long-term administration of intravenous alpha1-antitrypsin (AAT) in 14 patients with hereditary AAT deficiency and COPD. During the 12- to 48- month observation period, 12 to 14 patients had stabilization of functional status; 4 patients had reductions in hospitalizations. Thirteen of 14 patients had no decline in pulmonary function. Three patients had self-limited adverse reactions to the AAT with one patient requiring a brief hospitalization.


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J. G. W. Burdon, S. Brenton, M. Ayad, K. Knight, and J. Lieberman
Augmentation Therapy in {alpha}1-Antitrypsin Deficiency
Chest, August 1, 2001; 120(2): 687 - 687.
[Full Text] [PDF]

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S. A. Alkins and P. O’Malley
Should Health-Care Systems Pay for Replacement Therapy in Patients With {alpha}1-Antitrypsin Deficiency?: A Critical Review and Cost-Effectiveness Analysis
Chest, March 1, 2000; 117(3): 875 - 880.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the American College of Chest Physicians.