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Chest, Vol 105, 1701-1704, Copyright © 1994 by American College of Chest Physicians

ARTICLES

Effects of aerosol ipratropium bromide on cardiac vagal tone

PM Lehrer, SM Hochron, L Rausch and R Carr
UMDNJ-Robert Wood Johnson Medical School, Piscataway.

Thirty-one adult asthmatic subjects, aged 18 to 40 years, were administered both ipratropium bromide and placebo, in two sessions, held at least 2 days apart, in balanced order. Pulmonary function, heart period (milliseconds between heart beats), and respiratory sinus arrhythmia (a measure of cardiac vagal tone) were assessed before drug administration and 45 min thereafter. Ipratropium bromide had no significant effect on cardiac vagal tone, while it did produce improvement in pulmonary function.


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 Am. J. Physiol. Heart Circ. Physiol.Home page
N. D. Giardino, R. W. Glenny, S. Borson, and L. Chan
Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humans
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1585 - H1591.
[Abstract] [Full Text] [PDF]


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Copyright © 1994 by the American College of Chest Physicians.