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Chest, Vol 105, 1765-1769, Copyright © 1994 by American College of Chest Physicians

ARTICLES

Aerosol characteristics of 99mTc-pentetic acid (DTPA) and synthetic surfactant (Exosurf)

RE Coleman, N MacIntyre, G Snyder, E Pattishall and D Zaccardelli
Department of Radiology, Duke University Medical Center, Durham, NC 27710.

This study evaluated the feasibility of using 99mTc-pentetic acid (DTPA) as a radioactive tracer for aerosolized synthetic surfactant (DPPC, cetyl alcohol, tyloxapol). The 99mTc-DTPA was admixed with surfactant and aerosolized using a nebulizer system interfaced to a ventilator with a cascade impactor attached to the endotracheal tube. Particle size distribution for DPPC, cetyl alcohol, and 99mTc-DTPA were almost identical during the 0- to 15-, 15- to 30-, and 0- to 30-min collection periods. Tyloxapol exhibited a unique distribution pattern with increased deposition in large (> 10 microns) and small (0.65 to 1.1 microns) particles. The mass median aerodynamic diameter for all aerosolized components was in the respirable range of 2.1 to 2.5 microns. A mixture of 99mTc-DTPA with synthetic surfactant appears to be a reasonable method to evaluate surfactant deposition.


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