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(Chest. 1994;106:100-104.)
© 1994 American College of Chest Physicians

Progressive Bronchial Obstruction During the Acute Stage of Respiratory Tract Infection in Asthmatic Children

Shinya Kondo M.D., F.C.C.P.1; Masaki Ito M.D.1; Masamine Saito M.D.2; Mitsuko Sugimori M.D.1; and Hiroko Watanabe M.D.3

1 From the Tokyo Metropolitan Children's Hospital, Tokyo
2 From the Department of Pediatrics, Keio University Hospital, Tokyo
3 From the Children's Asthmatic Center, Kawasaki City Ida Hospital, Kawasaki City, Japan

To study the time-course of infectious asthma, we retrospectively examined FEV1 from 5 days before to 10 days after the onset of illness in 31 asthmatic children (20 boys and 11 girls), aged 8 to 12 years. Infections were confirmed by a rise of at least fourfold in serum compliment fixation titers (respiratory syncytial virus, adenovirus, and Mycoplasma pneumoniae) and hemoaggulutination inhibition titers (parainfluenza virus types 1, 2, and 3). All the patients had 20 percent or more fall in FEV1 from baseline value during acute phase, but were clinically tolerable and required minimum or no bronchodilators. Regardless of infectious agent, FEV1 began to fall on the first disease day or the previous day, and deteriorate for the first few days. Mean(SD) maximum fall in FEV1 ranged from 39(12) percent to 45(20) percent. Thereafter, FEV1 began to improve and returned to the preillness level by the seventh to tenth day. These results suggest that progressive bronchial obstruction may be inevitable during the acute stage of any infectious asthma.

Key Words: infectious asthma • Mycoplasma pneumoniae • respiratory virus

Submitted on September 8, 1993
Accepted on November 22, 2007




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