Chest Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Uh, S.
Right arrow Articles by Park, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uh, S.
Right arrow Articles by Park, C. S.
(Chest. 1994;106:161-165.)
© 1994 American College of Chest Physicians

The Clearance Rate of Alveolar Epithelium Using 99mTc-DTPA in Patients With Diffuse Infiltrative Lung Diseases

Sootaek Uh M.D.1; Sang Moo Lee M.D.1; Hyeon Tae Kim M.D.1; Yeontae Chung M.D.1; Yong Hoon Kim M.D.1; and Choon Sik Park M.D.1

1 From the Department of Internal Medicine, College of Medicine, Soonchunhyang University Hospital, Seoul, Korea

The early diagnosis of diffuse infiltrative lung disease (DILD) is important in prognosis and it is necessary to develop a noninvasive, inexpensive, and rapid diagnostic tool for suspected cases of DILD. Thus, we measured the epithelial permeability via radioisotope (99mTc-DTPA) in 22 patients with DILD for clinical application of the clearance rate (T1/2LB) of radioisotope on the early diagnosis of DILD. We divided the patients with DILD into the early and late stages according to the derangements of the diffusion capacity for carbon monoxide. The T1/2LB in patients with DILD were significantly shorter when compared with those with normal control in all lobes. However, 40 to 58 percent of T1/2LB in patients with DILD overlapped normal values (2 SDs of mean of T1/2LB of normal control) dependent on specific lung regions. The T1/2LB of patients with early-stage DILD was longer than that of patients with late-stage DILD in right upper and middle lobes. Although T1/2LB of 99mTc-DTPA, the index of alveolar epithelial permeability, was shortened in patients with DILD with normal diffusing capacity, it was difficult to detect early-stage DILD by measuring alveolar epithelial permeability because of many overlaps of T1/2LB between early-stage DILD and normal control.

Key Words: clearance • diffuse infiltrative lung disease • permeability

Submitted on January 25, 1993
Accepted on December 9, 2007




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Suga, Y. Yuan, N. Ogasawara, T. Tsukuda, and N. Matsunaga
Altered Clearance of Gadolinium Diethylenetriaminepentaacetic Acid Aerosol from Bleomycin-injured Dog Lungs: Initial Observations
Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1704 - 1710.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
J. M. Singh, V. A. Palda, M. B. Stanbrook, and K. R. Chapman
Corticosteroid Therapy for Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review
Arch Intern Med, December 9, 2002; 162(22): 2527 - 2536.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
N Mogulkoc, M H Brutsche, P W Bishop, B Murby, M S Greaves, A W Horrocks, M Wilson, C McCullough, M Prescott, and J J Egan
Pulmonary 99mTc-DTPA aerosol clearance and survival in usual interstitial pneumonia (UIP)
Thorax, December 1, 2001; 56(12): 916 - 923.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
D. M Mitchell and A. Woodcock
Introduction
Thorax, August 1, 1999; 54(90002): S1 - 1.
[PDF]

Home page
 ThoraxHome page
B. T. SOCIETY and S. O. C. COMMITTEE
The Diagnosis, Assessment and Treatment of Diffuse Parenchymal Lung Disease in Adults---British Thoracic Society recommendations
Thorax, April 1, 1990; 54(90001): 1S - 28.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American College of Chest Physicians.