Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ungerer, J. P.J.
Right arrow Articles by Bissbort, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ungerer, J. P.J.
Right arrow Articles by Bissbort, S. H.
(Chest. 1994;106:33-37.)
© 1994 American College of Chest Physicians

Significance of Adenosine Deaminase Activity and Its Isoenzymes in Tuberculous Effusions

Jacobus P.J. Ungerer M.Med.1; Heila M. Oosthuizen M.Sc.1; Johannes H. Retief M.Med.2; and Siegbert H. Bissbort Ph.D.1

1 From the Department of Chemical Pathology, Medical Faculty, University of Pretoria, Pretoria, South Africa
2 From the Department of Internal Medicine, Medical Faculty, University of Pretoria, Pretoria, South Africa

Adenosine deaminase (ADA) activity is increased in effusions caused by certain clinical conditions including tuberculosis and bacterial infections. In this study, the ADA isoenzyme patterns in tuberculous and parainfective effusions were investigated to determine the isoenzyme responsible for this increase in activity. Fifty-one tuberculous effusions and six parainfective effusions were investigated. All effusions had increased ADA activity (median values of 126 and 127 units/L, respectively). In the tuberculous effusions, ADA2 isoenzyme was found to be primarily responsible for total activity, with a median contribution of 88 percent. The ADA1 (both ADA1m and ADA1c isoenzymes) was the major isoenzyme in the parainfective effusions with a median contribution of 70 percent. The ADA2 isoenzyme activity most likely reflects monocyte-macrophage turnover or activity, while ADA1 probably originates from lymphocytes or neutrophils. It is therefore essential to determine the isoenzyme profile when interpreting ADA activity levels in effusions. The measurement of the individual isoenzymes will enhance the diagnostic utility of ADA activity determinations in pleural effusions.

Submitted on May 10, 1993
Accepted on November 30, 2007




This article has been cited by other articles:


Home page
 ChestHome page
A. Gopi, S. M. Madhavan, S. K. Sharma, and S. A. Sahn
Diagnosis and Treatment of Tuberculous Pleural Effusion in 2006
Chest, March 1, 2007; 131(3): 880 - 889.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Y. P. Kataria and I. Khurshid
Adenosine Deaminase in the Diagnosis of Tuberculous Pleural Effusion
Chest, August 1, 2001; 120(2): 334 - 336.
[Full Text] [PDF]

Home page
 ChestHome page
Y. C. G. Lee, J. T. Rogers, R. M. Rodriguez, K. D. Miller MD, and R. W. Light
Adenosine Deaminase Levels in Nontuberculous Lymphocytic Pleural Effusions
Chest, August 1, 2001; 120(2): 356 - 361.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. B. J Roth
Searching for Tuberculosis in the Pleural Space
Chest, July 1, 1999; 116(1): 3 - 5.
[Full Text] [PDF]

Home page
 Arch Intern MedHome page
L. Valdes, D. Alvarez, E. San Jose, P. Penela, J. M. Valle, J. M. Garcia-Pazos, J. Suarez, and A. Pose
Tuberculous Pleurisy: A Study of 254 Patients
Arch Intern Med, October 12, 1998; 158(18): 2017 - 2021.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1994 by the American College of Chest Physicians.