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(Chest. 1994;106:458-461.)
© 1994 American College of Chest Physicians

Roxithromycin Reduces the Degree of Bronchial Hyperresponsiveness in Children With Asthma

Toshio Shimizu M.D.1; Masahiko Kato M.D.1; Hiroyuki Mochizuki M.D.1; Kenichi Tokuyama M.D.1; Akihiro Morikawa M.D.1; and Takayoshi Kuroume M.D.1

1 From the Department of Pediatrics, Gunma University, School of Medicine, Maebashi, Gunma, Japan

We evaluated the effects of a new semisynthetic macrolide antibiotic, roxithromycin, on the bronchial hyperresponsiveness to histamine in children with asthma. Twelve hospitalized asthmatic children, aged 11 to 15 years (mean age, 12.9 years), were enrolled in this study. They were treated with 150 mg of roxithromycin once a day orally for 8 weeks without any side effects. The PC20 value 4 or 8 weeks after the administration of roxithromycin increased significantly over the initial values (p<0.05, p<0.01, respectively). No significant change was observed in serum theophylline concentrations during this study. Serum cortisol level in the morning did not change after the administration of roxithromycin for 4 weeks. These results suggest that administration of roxithromycin may act favorably in the treatment of childhood asthma.

Submitted on August 10, 1993
Accepted on December 21, 2007




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