| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
1 From the Department of Medicine, Respiratory Division, St. Michael's Hospital, University of Toronto, Toronto
2 From the Department of Medicine, Pulmonary and Critical Care Medicine, Case Western Reserve University, Cleveland
This study addresses the hypothesis that patients with obstructive sleep apnea, who exhibit recurrent episodes of oxygen desauration at night, have higher hematocrit levels than nonapneic control subjects. We prospectively studied 624 patients referred to the sleep disorders center at St. Michael's Hospital because of suspicion of sleep apnea. All patients had nocturnal polysomnography and measurements of hematocrit level, hemoglobin value, WBC count, and platelet count. Smoking history and awake oxygen saturation (SaO2) was recorded in all of them. Nocturnal oxygenation was assessed using three indices: lowest nocturnal SaO2 (LoSaO2), mean nocturnal SaO2 (MnSaO2), and percent of total sleep time spent at SaO2 lower than 85 percent (TST85%). Patients with TST85% in the lowest quartile (TST85%=0) had minimally lower hematocrit levels than patients with TST85% in the highest quartile (8
TST85%90): 0.41±0.03 vs 0.40±0.02 in female subjects and 0.45±0.05 vs 0.43±0.05 in male subjects, respectively (p<0.05). Multiple linear regression analysis revealed that MnSaO2, age, and pack-years of smoking were significant predictors of hematocrit level, but they accounted for only 9 percent of the variability in hematocrit level (multiple R2=0.087; p<0.05). We conclude that intermittent nocturnal hypoxemia during episodes of apnea does not lead to clinical polycythemia, but is associated with minor elevations in hematocrit value. These small elevations are unlikely to be useful as markers of hypoxic stress associated with sleep apnea.
This article has been cited by other articles:
|
|
 |
|
  L. J. Olson, E. J. Olson, and V. K. Somers Obstructive Sleep Apnea and Platelet Activation: Another Potential Link Between Sleep-Disordered Breathing and Cardiovascular Disease Chest, August 1, 2004; 126(2): 339 - 341. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bradford Festschrift for R. G. O'Regan - Sensing and adaptation to alterations in respiratory gases: oxygen and carbon dioxide: Effects of chronic intermittent asphyxia on haematocrit, pulmonary arterial pressure and skeletal muscle structure in rats Exp Physiol, January 1, 2004; 89(1): 44 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. M. Shamsuzzaman, B. J. Gersh, and V. K. Somers Obstructive Sleep Apnea: Implications for Cardiac and Vascular Disease JAMA, October 8, 2003; 290(14): 1906 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. T. LEUNG and T. DOUGLAS BRADLEY Sleep Apnea and Cardiovascular Disease Am. J. Respir. Crit. Care Med., December 15, 2001; 164(12): 2147 - 2165. [Full Text] [PDF]
|
|
|
|
 |
|
 M. McGuire and A. Bradford Chronic intermittent hypercapnic hypoxia increases pulmonary arterial pressure and haematocrit in rats Eur. Respir. J., August 1, 2001; 18(2): 279 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Fagan Physiological and Genomic Consequences of Intermittent Hypoxia: Selected Contribution: Pulmonary hypertension in mice following intermittent hypoxia J Appl Physiol, June 1, 2001; 90(6): 2502 - 2507. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
