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(Chest. 1994;106:1152-1155.)
© 1994 American College of Chest Physicians

Acute Pneumonitis After Subcutaneous Injections of Silicone for Augmentation Mammaplasty

Young-Fa Lai M.D., F.C.C.P.1; Tung-Ying Chao M.D.1; and Sui-Liong Wong M.D., F.C.C.P.1

1 From the Division of Chest, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center. Taiwan, Republic of China

In a period of 3 years, seven cases of acute pneumonitis have been found after patients have been subcutaneously injected with silicone for the sole purpose of augmentation mammaplasty. Adverse symptoms following these silicone injections were fever, hypoxemia, hemoptysis, and abnormal diffuse bilateral alveolar infiltrates in both lungs. Pulmonary hemorrhaging occurred, and this was substantiated by using the bronchoscope with the bronchealveolar lavage (BAL). The alveolar macrophage obtained from the BAL contained large quantities of pleomorphic cytoplasmic particles, which in actual fact were silicone particles. They were identified as silicone by scanning electron microscopy and energy-dispersive analysis of x-rays. This evidently showed that silicone diffusion into the circulatory system and subsequent embolization of the lung. Pulmonary function studies had shown restrictive changes with increase or normal single-breath carbon monoxide diffusing capacity (Dsb). Perfusion lung scans were interpreted as showing diffuse abnormalities consisting of decreased peripheral uptake. Acute hypoxemic respiratory failure was noted in four of these patients. Silicone injections of this nature were therefore a respiratory risk and caused the inducement of pneumonitis.

Key Words: augmentation mammaplasty • bronchoalveolar lavage • pneumonitis • silicone

Submitted on April 29, 1993
Accepted on February 24, 1994




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