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(Chest. 1994;106:1304-1305.)
© 1994 American College of Chest Physicians

Sarcoid Reactions in Cystic Duct Carcinoma

Marc Klein M.D.1; Pierre Kaminsky M.D.1; Joelle Deibener M.D.1; Marie-Pierre Cocciale M.D.1; and Michel Duc M.D.1

1 From the Service de Médecine J, Centre Hospitalier Universitaire de Nancy, Hôpitaux de Brabois, Vandoeuvre-lés Nancy, France

A diagnosis of sarcoidosis was evoked in a 61-year-old man on clinical and histologic bases. Nevertheless, a bile duct carcinoma was disclosed in association with the discovery of generalized sarcoid-like granulomas. This is only the third time that such an association has been described. HLA-B8, DR3, and DRw52 antigens were found, suggesting that altered immunologic mechanisms could play a role in the pathogenesis of this sarcoid-like reaction.

Key Words: carcinoma • concomitant disease • cystic duct • sarcoid reaction






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