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(Chest. 1994;106:1443-1447.)
© 1994 American College of Chest Physicians

Assessment of an Ultrathin Bronchoscope That Allows Cytodiagnosis of Small Airways

Mitsuru Tanaka M.D., F.C.C.P.1; Hajime Takizawa M.D., F.C.C.P.2; Masaru Satoh M.D.3; Yasumasa Okada M.D., F.C.C.P.3; Fumihiro Yamasawa M.D.3; and Akira Umeda M.D.3

1 From the Department of Diagnostic Radiology, School of Medicine, Keio University, Tokyo, Japan
2 From the Department of Medicine and Physical Therapy, School of Medicine, University of Tokyo, Tokyo, Japan
3 From the Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan

We developed a new type of bronchoscope (BF-2.7T) and cytology brush (BC-0.7T) that permit collection of pulmonary cells during direct observation of the small airways. This kind of cell collection has been previously impossible. With our cytology brush, 3.58±2.76x 104 cells were collected from small airways. The rate of living cells was 33.13±3.61 percent from the small airways. Analysis of endoscopic findings and investigation of pulmonary cells are very important for elucidating the pathophysiologic state of the small airways. The use of the BF-2.7T allowed collection of cancer cells under direct endoscopic vision in all five patients with peripheral lung cancer. They also contribute to our understanding of the relationship between exogenous factors and cells that compose the lung, and will provide means for treatment and prevention of diseases.

Key Words: cell brush (BC-0.7T) • small airways • small airway epithelial cells • ultrathin bronchoscope (BF-2.7T)

Submitted on December 16, 1993
Accepted on March 9, 1994




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