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(Chest. 1994;106:1595-1596.)
© 1994 American College of Chest Physicians

Primary Pulmonary Germ Cell Tumor With Blastomatous Differentiation

Roberta R. Miller M.D.1; Katerine Champagne M.D.2; and R. C. Nevin Murray M.D.2

1 From the Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada
2 From the Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

We describe the clinical and pathologic findings of a patient with mixed blastoma-germ cell malignancy primary in the lung. Serum alpha-fetoprotein levels were elevated at presentation, and normalized with anti-germ cell chemotherapy. The resection specimen contained massively necrotic germ cell tumor with viable mature neural tissue, plus viable biphasic blastoma with stromal bone and skeletal muscle differentiation. It is not clear whether the germ cell component represents unusual differentiation of a somatic cell line or whether the blastoma component represents an unusual pattern of teratomatous differentiation.






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Copyright © 1994 by the American College of Chest Physicians.