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(Chest. 1994;106:1597-1599.)
© 1994 American College of Chest Physicians

Recurrence of Sarcoidosis Following Bilateral Allogeneic Lung Transplantation

Fernando J. Martinez M.D.1; Jonathan B. Orens M.D.1; Michael Deeb M.D.2; Louis A. Brunsting M.D.2; Andrew Flint M.D.3; and Joseph P. Lynch III M.D.1

1 From the Department of Internal Medicine, the University of Michigan Medical Center, Ann Arbor
2 From the Department of Surgery, the University of Michigan Medical Center, Ann Arbor
3 From the Department of Pathology, the University of Michigan Medical Center, Ann Arbor

We report the first case of recurrent sarcoidosis manifested by clinical symptoms, radiographic abnormalities, and pathologic changes in a patient following sequential double allogeneic lung transplantation. A 40-year-old male patient underwent bilateral allogeneic lung transplantation for end-stage pulmonary sarcoidosis. Thirteen months posttransplantation, he developed fatigue, shortness of breath, and bilateral upper lobe pulmonary infiltrates. Transbronchial biopsy specimens revealed noncaseating granulomata. The patient's symptoms and radiographic abnormalities resolved with an increased dose of oral prednisone.




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