Chest ACCP Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jones, D. R.
Right arrow Articles by Murray, G. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jones, D. R.
Right arrow Articles by Murray, G. F.
(Chest. 1995;107:307-310.)
© 1995 American College of Chest Physicians

Preservation of Adenosine 5'-Triphosphate and Mitochondrial Function During Hypercalcemic Reperfusion Using Verapamil Cardioplegia

David R. Jones MD1; Albert E. Abbott Jr. MD1; Ronald C. Hill MD1; Kay C. Beamer MS1; Robert A. Gustafson MD1; and Gordon F. Murray MD1

1 From the Department of Surgery, West Virginia University, Morgantown, WV.

Immediate hypercalcemic reperfusion results in ventricular dysfunction and loss of high-energy stores. The purpose of this study was to evaluate the effect of verapamil cardioplegia on the preservation of myocardial energy stores, mitochondrial ultrastructure, and ventricular dysfunction in the postischemic rat heart during immediate hypercalcemic reperfusion. Rats in the control group were subjected to cardioplegia with potassium, while rats in groups 1 to 3 were subjected to the same with verapamil (0.5 mg/L). The control and group 1 rats underwent normocalcemic reperfusion and groups 2 and 3 rats underwent hypercalcemic reperfusion. Myocardial samples were analyzed for adenosine 5'-triphosphate (ATP) content and mitochondrial ultrastructural damage. Hemodynamic parameters of heart rate, aortic flow (AF), and postischemic rate of aortic pressure change (dP/dT) also were evaluated. Data were analyzed using analysis of variance. The ATP stores were preserved at greater than 100% control levels in hearts subjected to verapamil cardioplegia. There was no evidence of irreversible mitochondrial damage. Heart rate, AF, and dP/dT were significantly (p<0.05) depressed in hearts subjected to verapamil cardioplegia. This study suggests verapamil cardioplegia preserves ATP and mitochondrial function during immediate hypercalcemic reperfusion but does not improve postis-chemic hemodynamics.

Key Words: adenosine 5'-triphosphate (ATP) preservation • hypercalcemic reperfusion • verapamil cardioplegia

Submitted on December 27, 1993
Accepted on April 26, 1994




This article has been cited by other articles:


Home page
 CirculationHome page
E. G. Daoud, B. P. Knight, R. Weiss, M. Bahu, W. Paladino, R. Goyal, K. C. Man, S. A. Strickberger, and F. Morady
Effect of Verapamil and Procainamide on Atrial Fibrillation–Induced Electrical Remodeling in Humans
Circulation, September 2, 1997; 96(5): 1542 - 1550.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American College of Chest Physicians.