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(Chest. 1995;107:614-620.)
© 1995 American College of Chest Physicians

Usefulness of Morphometric Evaluation of Histopathologic Slides in Predicting Long-term Outcome of Patients With Squamous Cell Carcinoma of the Lung

A Preliminary Report

Fabíola Del Carlo Bernardi MD1; Vera Luiza Capelozzi MD, PhD1; Tereza Yae Takagaki MD, PhD2; Riad Naim Younes MD3; and Paulo Hilário Nascimento Saldiva MD, PhD, FCCP1

1 From the Laboratório de Poluição Atmosférica Experimental and Instituto do Coração, São Paulo, Brazil
2 From the Disciplina de Pneumologia, São Paulo, Brazil
3 From the Faculdade de Medicina da Universidade de São Paulo, Departamento de Cirurgia Torácica, Hospital A. C. Camargo, São Paulo, Brazil

The present work was designed to evaluate the role of morphometric parameters in contributing to establish prognosis in 35 patients who underwent surgical resection of squamous cell carcinoma (SCC) of the lung. Morphometric studies were performed by means of point counting techniques. Patients considered as disease-free survivors, ie, those without tumor recurrence for more than 60 months (n=6), were designated as DOWELL, whereas the remaining 29 patients comprised the DOBAD group. In order to characterize DOWELL patients, multivariate models combining numeric and categoric variables were constructed considering numeric variables (age and morphometric parameters) or indexes for categoric data such as stage, and presence of residual tumor. Staging, incomplete tumor resection, and nucleus-cytoplasm ratio were selected by the model as significantly associated with survival. In addition, nuclear volume contributed (although nonsignificantly per se) to further refine the model by increasing its r value. Our results indicate that histopathologic data, when evaluated quantitatively, could predict prognosis in patients with SCC, together with staging and clinical data and encourage the use of morphometric procedures in the histopathologic analysis of SCC.

Key Words: morphometry • prognostic indexes in lung cancer • pulmonary cancer • pulmonary pathology

Submitted on February 28, 1994
Accepted on July 25, 2007




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[Abstract] [Full Text] [PDF]


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