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(Chest. 1995;107:1009-1012.)
© 1995 American College of Chest Physicians

Effect of Inhaled Heparin on Methacholine-Induced Bronchial Hyperreactivity

Berrin Ceyhan MD1 and Turgay Celikel MD, FCCP1

1 From the Department of Pulmonary Medicine, Marmara University Faculty of Medicine, Istanbul, Turkey

Although heparin is used as an anticoagulant, its biologic function has remained unclear since the 1920s. Glycosaminoglycan heparin possesses multiple noncoagulant properties, including anti-inflammatory actions, and it is possible that heparin may inhibit airway hyperreactivity. Thus, the purpose of the present investigation was to study the effect of inhaled heparin on methacholine-induced bronchoconstriction. Thirteen subjects (7 women, 6 men) with mild asthma were included in the study. Bronchial provocation tests were performed in a single-blind, crossover, randomized order and repeated 45 min after placebo or aerosolized heparin inhalation (1,000 U/kg). The heparin inhibited bronchoconstriction induced by methacholine. In the methacholine challenge test, heparin treatment resulted in an increase in the mean PD20 over placebo: 5.26±4.80 mg/mL vs 10.57±5.72 mg/mL (p<0.0002). These data suggest that inhaled heparin may have an inhibitory role on methacholine bronchial challenge, possibly via a direct effect on smooth muscle.

Key Words: bronchial hyperreactivity • inhaled heparin • methacholine

Submitted on March 7, 1994
Accepted on August 4, 2007




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[Abstract] [Full Text] [PDF]


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