Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Farge, D.
Right arrow Articles by Payen, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Farge, D.
Right arrow Articles by Payen, D. M.
(Chest. 1995;107:1095-1100.)
© 1995 American College of Chest Physicians

Interactions Between Hemodynamic and Hormonal Modifications During Peep-induced Antidiuresis and Antinatriuresis

Dominique Farge MD, MSc1; Jean E. De La Coussaye MD2; Sadek Beloucif MD3; Marie D. Fratacci MD3; and Didier M. Payen MD, PhD3

1 From the Department of Internal Medicine, Saint Louis University Hospital, Paris, France
2 From the Department of Anesthesiology, Nîmes University Hospital, Nimes, France
3 From the Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, Paris, France

The interactions between hemodynamic and hormonal modifications during antidiuresis and antinatriuresis induced by positive end-expiratory pressure (PEEP) were studied in six patients under 15 cm H2O PEEP before PEEP and after the addition of lower body positive pressure (LBPP) to PEEP (PEEP+LBPP). We measured or calculated the following: cardiac index, systemic arterial, right atrial, pulmonary arterial, and pulmonary artery occlusive pressures; indexed renal blood flow (iodohippurate 131 sodium clearance); total blood volume (chromium 51 radiolabeled RBCs); glomerular filtration rate; urinary output; fractional excretion of sodium (FE Na+); plasma concentrations of antidiuretic hormone (ADH), plasma renin activity (PRA), norepinephrine and epinephrine; urinary concentration of PGE2 (PGE2u). Although LBPP application corrected PEEP deleterious effects on systemic and renal hemodynamics, sustained fall in Vu and in FE Na+ were observed. Antidiuresis was not due to ADH release. Sympathetic activation and high PRA appeared the main determinants of renal function alterations in PEEP ventilation.

Key Words: antidiuresis • antinatriuresis • lower body positive pressure • positive pressure breathing • renal function

Submitted on December 16, 1993
Accepted on September 8, 2007




This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
J.-Y. Lefrant, J.-M. Juan, P. Bruelle, R. Demaria, R. Cohendy, G. Aya, M.-C. Oliva-Lauraire, P. Peray, E. Robert, J.-E. de La Coussaye, et al.
Regional blood flows are affected differently by PEEP when the abdomen is open or closed: an experimental rabbit model: [L'influence de la PEP sur le debit sanguin regional est differente selon que l'abdomen est ferme ou ouvert : un modele experimental chez le lapin]
Can J Anesth, March 1, 2002; 49(3): 302 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Q. Fu, Y. Sugiyama, A. Kamiya, A. S. M. Shamsuzzaman, and T. Mano
Responses of muscle sympathetic nerve activity to lower body positive pressure
Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1254 - H1259.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American College of Chest Physicians.