Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aptecar, E.
Right arrow Articles by Nitenberg, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aptecar, E.
Right arrow Articles by Nitenberg, A.
(Chest. 1995;107:1266-1274.)
© 1995 American College of Chest Physicians

Early Impairment of Acetylcholine-Induced Endothelium-Dependent Coronary Vasodilation Is Not Predictive of Secondary Graft Atherosclerosis

Eduardo Aptecar MD1; Christophe Benvenuti MD2; Daniel Loisance MD2; Jean-Paul Cachera MD2; and Alain Nitenberg MD1

1 From the Service d'Explorations Fonctionnelles and Institut National de la Santé et de la Recherche Médicale Unité 251, CHU Xavier-Bichat, Paris
2 From the Service de Chirurgie Thoracique et Cardio-vasculaire and Centre National de la Recherche Scientifique URA 1431, Créteil, France

Study objective: To test the hypothesis that the magnitude of early constriction of coronary arteries to acetylcholine might be a useful predictor of secondary graft atherosclerosis.

Design: The responses of epicardial coronary arteries to stepwise intracoronary infusion of acetylcholine (10minus8M to 10minus5M) were compared in 7 control subjects and in 18 patients who had undergone transplants within 2 months after surgery.

Measurements and results: Vessel dimensions (percent basal diameter) were measured by quantitative angiography. Follow-up at 1 year showed angiographically normal coronary arteries in 12 patients (group 1) and coronary atherosclerosis in 6 patients (group 2). In control subjects, acetylcholine induced a dose-dependent dilation from 10minus8M to 10minus6M. No significant variation was observed at 10minus5M. In patients with transplants early after surgery, diameters did not vary significantly from base at 10minus8M in either group and constricted significantly at higher concentrations. Vasodilator responses to intracoronary isosorbide dinitrate were similar in both groups with transplants early after surgery, and at 1 year in group 1, but significantly lower than in control subjects.

Conclusions: In patients who had undergone transplants, acetylcholine-induced endothelium-dependent coronary artery dilation is similarly impaired early after surgery (within 2 months) in patients with and without coronary atherosclerosis at 1-year follow-up. Thus, response to acetylcholine is not a predictor of secondary atherosclerosis in patients with heart transplants.

Key Words: acetylcholine • coronary arteries • graft atherosclerosis • heart transplantation

Submitted on July 15, 1994
Accepted on October 6, 2007




This article has been cited by other articles:


Home page
 Eur Heart JHome page
G. Vassalli, A. Gallino, M. Weis, W. von Scheidt, L. Kappenberger, L.K. von Segesser, J.-J. Goy, and on behalf of the Working Group Microcirculation of
Alloimmunity and nonimmunologic risk factors in cardiac allograft vasculopathy
Eur. Heart J., July 1, 2003; 24(13): 1180 - 1188.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American College of Chest Physicians.