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(Chest. 1995;107:1328-1335.)
© 1995 American College of Chest Physicians

Exercise Testing in Pediatric Heart, Heart-Lung, and Lung Transplant Recipients

Patricia A. Nixon PhD1; F. Jay Fricker MD1; Blakeslee E. Noyes MD1; Steven A. Webber MBChB1; David M. Orenstein MD1; and John M. Armitage MD1

1 From the Children's Hospital of Pittsburgh and Departments of Pediatrics and Surgery University of Pittsburgh, and Cardinal Glennon Children's Hospital St. Louis

Cardiorespiratory responses to progressive exercise were examined in 38 children who had undergone heart (n=16), heart-lung (n=13), or double-lung (n=9) transplantation, and in 41 healthy controls. The four groups were similar in age, but the control subjects and heart transplant recipients were significantly larger than the heart-lung and lung recipients as assessed by body mass index (BMI). Time since transplant was significantly longer in the heart (601 days) compared with heart-lung (146 days) and lung (125 days) transplant groups. Physical work capacity and peak oxygen uptake were significantly reduced (43 to 64% of predicted) in the three transplant groups compared with the control group. Peak heart rate (percent predicted) was significantly higher in the control subjects (94%) compared with the heart (66%), heart-lung (70%), and lung (77%) transplant recipients. Peak minute ventilation was significantly higher in the control (72.9 L/min) and heart transplant (51.0 L/min) groups than the heart-lung (37.4 L/min) and lung (41.3 L/min) transplant groups. The control group had a higher peak tidal volume than the three transplant groups, and a higher peak respiratory rate than the lung transplant recipients. Correlational analysis revealed that physical work capacity (PWC) was significantly related to heart rate at peak exercise (HRpeak) and minute ventilation at peak exercise (VEpeak) in the heart transplant recipients, BMI, VEpeak, and FEV1 in the heart-lung transplant recipients, and BMI, HRpeak, VEpeak, FEV1, and number of days posttransplant in the lung transplant recipients. In addition to these variables, physical deconditioning and factors related to pharmacotherapy, infection, and rejection may also contribute to the decreased PWC observed in the transplant recipients.

Key Words: children • exercise testing • heart • heart-lung • lung transplantations

Submitted on June 20, 1994
Accepted on October 27, 2007




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