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(Chest. 1995;108:712-717.)
© 1995 American College of Chest Physicians

Chemoprophylaxis of Multidrug-Resistant Tuberculous Infection in HIV-Uninfected Individuals Using Ciprofloxacin and Pyrazinamide

A Decision Analysis

Jennifer P. Stevens 1 and Thomas M. Daniel MD, FCCP1

1 From the Center for International Health, Case Western Reserve University School of Medicine, Cleveland

Study objective: To evaluate the use of ciprofloxacin and pyrazinamide for the prophylaxis of individuals infected with multiply drug-resistant strains of Mycobacterium tuberculosis.

Design: Decision analysis, using software (SMLTREE). Probabilities based on published studies, with sensitivity analysis for each probability.

Setting: Health-care workers infected with multidrug-resistant strains of M tuberculosis.

Interventions: Prophylaxis with ciprofloxacin and pyrazinamide.

Measurements and results: We calculated the utilities of taking or not taking prophylaxis with ciprofloxacin and pyrazinamide. The decision analysis favored the use of ciprofloxacin-pyrazinamide prophylaxis by a small margin.

Conclusion: Ciprofloxacin-pyrazinamide prophylaxis should be considered for health-care workers infected with multiply drug-resistant M tuberculosis.

Key Words: chemoprophylaxis • ciprofloxacin • decision analysis • pyrazinamide • tuberculosis

Submitted on August 22, 1994
Accepted on April 12, 1995




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T. Papastavros, L. R. Dolovich, A. Holbrook, L. Whitehead, and M. Loeb
Adverse events associated with pyrazinamide and levofloxacin in the treatment of latent multidrug-resistant tuberculosis
Can. Med. Assoc. J., July 1, 2002; 167(2): 131 - 136.
[Abstract] [Full Text] [PDF]


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