Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beinert, T.
Right arrow Articles by Heyder, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beinert, T.
Right arrow Articles by Heyder, J.
(Chest. 1995;108:998-1003.)
© 1995 American College of Chest Physicians

Peripheral Airspace Dimensions in Patients With COPD

Thomas Beinert MD1; Peter Brand PhD2; Jürgen Behr MD3; Claus Vogelmeier MD3; and Joachim Heyder PhD2

1 From the GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Inhalationsbiologie, Oberschleissheim, Germany; Ludwig-Maximilians-Universität München, Klinikum Grosshadern, Abteilung für Pneumologie, München, Germany
2 From the GSF-Forschungszentrum fur Umwelt und Gesundheit, Institut für Inhalationsbiologie, Oberschleissheim, Germany
3 From Ludwig-Maximilians-Universität München, Klinikum Grosshadern, Abteilung für Pneumologie, München, Germany

Monodisperse aerosol particles can be used to assess noninvasively intrapulmonary airspace dimensions. Since emphysematic changes in the peripheral lung are difficult to detect with most of the common lung function tests, aerosol-derived airway morphometry was used to assess the peripheral airspace dimensions (EAD800) in 25 patients with COPD and in 36 healthy volunteers. Spirometric and body plethysmographic measurements were performed in all patients. In ten patients, high-resolution CT-derived mean lung density (MLD) was additionally assessed. In healthy subjects, EAD800 was 0.39±0.05 mm. In patients, EAD800 was significantly increased (0.82±0.33 mm). In a subset of nine patients with severe agr1-antitrypsin deficiency and clinically severe emphysema, EAD800 was even larger (1.14±0.31 mm). In patients, EAD800 correlated with MLD (r=minus0.82), diffusion capacity (DCO) (r=minus0.78), and FEV1 (r=minus0.75). Since MLD is considered a valid indicator for lung emphysema, the close correlation between EAD800 and MLD suggests that EAD800 reflects enlarged peripheral airspace dimensions in patients with emphysema.

Key Words: aerosol • airspace dimensions • COPD • lung • lung function test • quantitative HRCT

Submitted on September 16, 1993
Accepted on April 26, 1995




This article has been cited by other articles:


Home page
 Eur Respir JHome page
S. B. Shaker, N. Maltbaek, P. Brand, S. Haeussermann, and A. Dirksen
Quantitative computed tomography and aerosol morphometry in COPD and {alpha}1-antitrypsin deficiency
Eur. Respir. J., January 1, 2005; 25(1): 23 - 30.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 818 - 900.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. KOHLHÄUFL, P. BRAND, C. ROCK, T. RADONS, G. SCHEUCH, T. MEYER, H. SCHULZ, K. J. PFEIFER, K. HÄUSSINGER, and J. HEYDER
Noninvasive Diagnosis of Emphysema . Aerosol Morphometry and Aerosol Bolus Dispersion in Comparison to HRCT
Am. J. Respir. Crit. Care Med., September 1, 1999; 160(3): 913 - 918.
[Abstract] [Full Text]

Home page
 ChestHome page
P. Brand, M. Kohlhaufl, T. Meyer, T. Selzer, J. Heyder, and K. Hau{beta}inger
Aerosol-Derived Airway Morphometry and Aerosol Bolus Dispersion in Patients With Lung Fibrosis and Lung Emphysema
Chest, August 1, 1999; 116(2): 543 - 548.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. S. Rosenthal
Aerosol probes of lung injury in a 28-wk longitudinal study of mild experimental emphysema in dogs
J Appl Physiol, February 1, 1999; 86(2): 725 - 731.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the American College of Chest Physicians.