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(Chest. 1996;109:94-99.)
© 1996 American College of Chest Physicians

Soluble Intercellular Adhesion Molecule 1 (ICAM-1) Antigen in Sera of Bronchial Asthmatics

Yutaro Shiota MD1; James G. Wilson MD2; Masaomi Marukawa MD3; Tetsuya Ono MD3; and Masaro Kaji MD3

1 From the Department of Clinical Research, Kure Kyousai Hospital, Kure, Japan
2 From the Department of Veterans Affairs Medical Center and University of Mississippi Medical Center, Jackson, Miss.
3 From the Department of Internal Medicine, Kure Kyousai Hospital, Kure, Japan

Previous studies have suggested that intercellular adhesion molecule 1 (ICAM-1, CD54) may be involved in the pathogenesis of asthma. In addition, a soluble form of ICAM-1 (sICAM-1) has been detected in increased concentrations in the sera of patients with certain inflammatory conditions. To determine whether bronchial asthma is associated with increased levels of sICAM-1 in serum and to assess the effects of therapy on these levels, the concentrations of sICAM-1 were measured in sera of healthy donors and asthmatic patients. The mean (±SD) level of serum sICAM-1 for 60 asthmatic patients (304.0±82.5 ng/mL) was significantly higher than that for 39 healthy volunteers (260.9±67.2 ng/mL; p=0.004). Twenty-two patients considered to have atopic asthma and 24 patients with nonatopic asthma did not differ in their levels of sICAM-1. In 14 patients, serum concentrations of sICAM-1 were higher during asthma attacks than in the same patients during remission (p=0.035). Serum sICAM-1 levels were lower in nine patients during treatment with oral prednisolone (2.5 to 40 mg/d) than during periods without systemic corticosteroid therapy (p=0.002). Thus, active bronchial asthma is associated with the presence of increased levels of sICAM-1 in serum, and these levels may be modulated by corticosteroid therapy.

Key Words: adhesion molecule • bronchial asthma • ELISA • intercellular adhesion molecule 1

Submitted on August 4, 1994
Accepted on August 15, 1995




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