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(Chest. 1996;109:348-352.)
© 1996 American College of Chest Physicians

Iodinated Glycerol Has No Effect on Pulmonary Function, Symptom Score, or Sputum Properties in Patients With Stable Chronic Bronchitis

Bruce K. Rubin MD, FCCP1; Oscar Ramirez MD1; and Jill A. Ohar MD, FCCP2

1 From the Pediatric Research Institute Mucociliary Physiology Laboratories, St. Louis University School of Medicine, St. Louis
2 From the Division of Pulmonary and Occupational Medicine, St. Louis University School of Medicine, St. Louis

Study objective: It has been reported that therapy with iodinated glycerol (IG) can improve the quality of life for patients with chronic bronchitis. The purpose of this study was to determine the effects of IG therapy on the quality of life, pulmonary function, and on the properties of sputum collected from adults with stable chronic bronchitis.

Design: Thirty-two week, double-blind, randomized, placebo-controlled cross-over study.

Setting: A university outpatient pulmonary clinic.

Participants: Twenty-six adults with stable chronic bronchitis completed the study; 28 completed the first treatment arm.

Interventions: Sixteen weeks each of placebo or IG 60 mg qid.

Measurements: First, pulmonary function by spirometry and plethysmography. Second, symptom score measured using a questionnaire. Third, sputum bulk and surface rheology, spinnability, mucociliary transportability and cough transportability.

Results: There were no significant changes in pulmonary function, clinical scores, or sputum properties related to therapy with IG. There was a significant improvement in the Global Petty score after both IG (p=0.01) and placebo (p<0.01) when compared with baseline, but there was no difference between treatment periods. There was a positive correlation between changes in the Global score during therapy and changes in sputum spinnability (p<0.01, r=0.38).

Conclusions: This study clearly demonstrates that in chronic bronchitis, 16 weeks of therapy with IG does not produce any appreciable effect on pulmonary function, well being, or on sputum viscoelasticity or clearability.

Key Words: chronic bronchitis • cough • iodinated glycerol • mucociliary clearance • mucolytics

Submitted on July 13, 1995
Accepted on September 27, 2007




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