| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
1 From the Service de Radiologie, Hopital Cardiovasculaire et Pneumologique, Lyon, France
2 From the Service d'Exploration Fonctionnelle Respiratoire, Hopital Cardiovasculaire et Pneumologique, Lyon, France
3 From the Service de Pneumologie, Hopital Cardiovasculaire et Pneumologique, Lyon, France
Purpose: To evaluate, on thin-section CT scans, the prevalence of emphysema in patients with bronchiectasis and to correlate the results of thin-section CT scans with the results of pulmonary function tests, in order to question whether there was a particular functional test profile in this group of patients.
Patients and methods: This is a retrospective study including 90 patients having both thin-section CT scans and pulmonary function tests for bronchiectasis. A CT scoring system was established for assessing the airway disease by the severity and extent of bronchiectasis and by the extent of emphysema. CT scans were reviewed independently by two reviewers and final interpretation was obtained by consensus. Results of thin-section CT scans were correlated with results of pulmonary function tests, including FEV1 and FEV1/FVC to assess air-way obstruction, total lung capacity and residual volume to assess air trapping, and diffusing capacity for carbon monoxide/alveolar volume (DCO/VA).
Results: CT evidence of emphysema, which was noted in 45% of the patients (n=41), was mainly localized in the same bronchopulmonary segments as bronchiectasis. The presence of emphysema was in relation to the extent and to the severity of bronchiectasis. Only eight patients with CT evidence of emphysema had functional evidence of emphysema (20%). When comparing the group of patients with CT evidence of emphysema with the group of patients with no CT evidence of emphysema, the group of patients with CT evidence of emphysema had significantly higher airflow obstruction and air trapping, had significantly lesser value of diffusing capacity, but with no decreased gas transfer (DCO/VA >80%).
Conclusion: Our series suggests that there is a high prevalence of emphysema in patients with bronchiectasis. Emphysema that was not suggested using pulmonary function tests in most of the cases could explain in part the higher airway obstruction observed in the group of patients with CT evidence of emphysema. This study could support the suggestive notion that emphysema, which was mainly localized in bronchiectatic lobes, could be due to the inflammatory airway process.
Key Words: bronchiectasis • emphysema • lung • pulmonary function tests • thin-section CT
Submitted on April 18, 1995
Accepted on September 6, 2007
This article has been cited by other articles:
|
|
 |
|
  A. H. Alzeer, A. F. Al-Mobeirek, H. A. K. Al-Otair, U. A. F. Elzamzamy, I. A. Joherjy, and A. S. Shaffi Right and Left Ventricular Function and Pulmonary Artery Pressure in Patients With Bronchiectasis Chest, February 1, 2008; 133(2): 468 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. de Jong, N. L. Muller, P. D. Pare, and H. O. Coxson Computed tomographic imaging of the airways: relationship to structure and function Eur. Respir. J., July 1, 2005; 26(1): 140 - 152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.M. Vignola, F. Paganin, L. Capieu, N. Scichilone, M. Bellia, L. Maakel, V. Bellia, P. Godard, J. Bousquet, and P. Chanez Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD Eur. Respir. J., December 1, 2004; 24(6): 910 - 917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Ooi, P. L. Khong, M. Chan-Yeung, J. C. M. Ho, P. K. S. Chan, J. C. K. Lee, W. K. Lam, and K. W. T. Tsang High-Resolution CT Quantification of Bronchiectasis: Clinical and Functional Correlation Radiology, December 1, 2002; 225(3): 663 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.E. Sheehan, A.U. Wells, S.J. Copley, S.R. Desai, S.J. Howling, P.J. Cole, R. Wilson, and D.M. Hansell A comparison of serial computed tomography and functional change in bronchiectasis Eur. Respir. J., September 1, 2002; 20(3): 581 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Barker Bronchiectasis N. Engl. J. Med., May 2, 2002; 346(18): 1383 - 1393. [Full Text] [PDF]
|
|
|
|
|
|
D.M. Hansell Small airways diseases: detection and insights with computed tomography Eur. Respir. J., June 1, 2001; 17(6): 1294 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H R Roberts, A U Wells, D G Milne, M B Rubens, J Kolbe, P J Cole, and D M Hansell Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests Thorax, March 1, 2000; 55(3): 198 - 204. [Abstract] [Full Text]
|
|
|
|
|
|
A. Cuvelier, J.-F. Muir, M.-F. Hellot, D. Benhamou, J.-P. Martin, J. Benichou, and R. Sesboue Distribution of {alpha}1-Antitrypsin Alleles in Patients With Bronchiectasis Chest, February 1, 2000; 117(2): 415 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. KOHLHÄUFL, P. BRAND, C. ROCK, T. RADONS, G. SCHEUCH, T. MEYER, H. SCHULZ, K. J. PFEIFER, K. HÄUSSINGER, and J. HEYDER Noninvasive Diagnosis of Emphysema . Aerosol Morphometry and Aerosol Bolus Dispersion in Comparison to HRCT Am. J. Respir. Crit. Care Med., September 1, 1999; 160(3): 913 - 918. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
