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(Chest. 1996;109:651-658.)
© 1996 American College of Chest Physicians

Respiratory Effort

A Factor Contributing to Sleep Propensity in Patients With Obstructive Sleep Apnea

Monica Zamagni MD1; Emilia Sforza MD1; An Boudewijns MD1; Christophe Petiau MD1; and Jean Krieger MD1

1 From the Sleep Disorders Unit, University Hospital, Strasbourg, France

To test the hypothesis that respiratory effort during obstructive apneas contributes, together with hypoxemia and sleep fragmentation, to excessive daytime sleepiness, we investigated the relationship between daytime sleepiness and polysomnographic variables in 44 patients with obstructive sleep apnea (OSA). In all patients, daytime sleep propensity was assessed by an 11-item standardized self-questionnaire yielding a sleepiness score and by a modified sleep latency test yielding a mean sleep latency. Respiratory effort during apneas was evaluated by measuring esophageal pressure swings using an esophageal balloon. Within each apneic cycle, we measured the esophageal pressure swings during the first three and the last three occluded efforts during the apnea to define the overall increase, its ratio to apnea duration, and the maximal effort developed during obstruction. In the group of patients as a whole, the sleepiness score was negatively correlated with the mean sleep latency (r=minus0.38, p=0.01). The sleepiness score was correlated with the indexes of respiratory effort during apneas (ie, the overall increase, its ratio to apnea duration, and the maximal end-apneic swing in esophageal pressure) and with the apnea+hypopnea index. The mean sleep latency was correlated with all indexes of nocturnal hypoxemia (ie, the mean lowest oxyhemoglobin saturation [SaO2] and the index of apnea associated with a fall in SaO2 below 90% and 80%). We conclude that the degree of respiratory effort during obstructive apneas contributes to self-rated sleep propensity in patients with OSA.

Key Words: chronic fatigue • respiratory effort • sleep apnea syndrome • sleepiness

Submitted on December 21, 1994
Accepted on October 10, 1995




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Copyright © 1996 by the American College of Chest Physicians.