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(Chest. 1996;109:718-726.)
© 1996 American College of Chest Physicians

p53 Mutations in Non-small Cell Lung Carcinomas in Hong Kong

Maria Li Lung PhD1; Maria P. Wong MBBS2; Mette T. Skaanild PhD1; C. L. Fok MPhil1; Wah Kit Lam MD, FCCP1; and Wing Wai Yew MBBS, FCCP1

1 From the Department of Biology, Hong Kong University of Science and Technology, Queen Mary Hospital, University of Hong Kong, Hong Kong
2 From the Department of Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong

Lung resections from 50 Chinese patients in Hong Kong diagnosed as having non-small cell lung carcinoma were examined for the presence of mutations in the p53 gene by polymerase chain reaction single-stranded conformation polymorphism methods and for aberrant protein expression by immunostaining techniques. Eight-point mutations in the evolutionarily conserved exon 5 through 8 regions were detected. Abnormal expression of p53 detectable by immunostaining techniques was seen in 23 specimens tested. There was no statistically significant correlation between the detection of p53 aberrations and age, sex, smoking history, histologic type, and tumor stage. Aberrant p53 protein levels detectable by immunostaining were significantly associated with the clinical and nodal staging of the tumors.

Key Words: Hong Kong • lung carcinoma • p53

Submitted on May 24, 1995
Accepted on September 25, 2007




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Copyright © 1996 by the American College of Chest Physicians.