| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
1 From the Division of Pediatric Pulmonology, Madigan Army Medical Center, Tacoma, Wash.
Study objective: To determine whether breathing a blend of 70% helium:30% oxygen (heliox) would improve pulmonary function, decrease clinical score, and improve the sensation of dyspnea in children hospitalized with acute severe asthma.
Design: Prospective, randomized, double-blind, crossover study.
Setting: The inpatient pediatric service of a military, tertiary care, teaching hospital.
Patients: Children 5 to 18 years who required hospital admission for treatment of acute asthma.
Interventions: All patients received 5 mg of nebulized albuterol every 1 to 4 h, with a dose given within 30 min of the start of the study, and IV administered methylprednisolone. Patients breathed heliox and a 30% oxygen-enriched air mixture for 15 min each in random order.
Measurements and results: Clinical score, dyspnea score, oxygen saturation, heart rate, and respiratory rate, followed by FVC, FEV1, peak expiratory flow rate (PEFR), and, mean midexpiratory flow rate (FEF25-75) were obtained at study entry, 15 min after breathing the first gas mixture (heliox or air per randomization), 15 min after breathing the second mixture, and again 15 min after stopping the second gas mixture (study end values). Eleven children were enrolled, and all completed the study. There were no significant differences between study entry and study end spirometric values. Using the paired t test, we found no significant differences between mean values (SD) of FEV1 and FVC obtained while breathing heliox vs air; FEV1-heliox, 53% (18%) of the predicted value; FEV1-air, 52% (16%) of the predicted value (p=0.36); FVC-heliox, 69% (22%) of the predicted value; and FVC-air, 70% (21%) of the predicted value (p=0.50). The differences in values for PEFR and FEF25-75 while breathing heliox vs air were small but did reach statistical significance in favor of heliox: PEFR-heliox, 56% (20%) of the predicted value; PEFR-air, 50% (16%) of the predicted value (p=0.04); FEF25-75-heliox, 32% (13%) of the predicted value; and FEF25-75-heliox, 29% (11%) of the predicted value (p=0.006). Heliox had no effect on either clinical or dyspnea scores.
Conclusion: The short-term inhalation of heliox did not benefit this group of children hospitalized with acute, severe asthma.
Key Words: asthma • children • heliox
Submitted on August 8, 1995
Accepted on December 5, 2007
This article has been cited by other articles:
|
|
 |
|
  S. Dhuper, S. Choksi, S. Selvaraj, G. Jha, A. Ahmed, H. Babbar, B. Walia, A. Chandra, V. Chung, and C. Shim Room Air Entrainment During {beta}-Agonist Delivery With Heliox. Chest, October 1, 2006; 130(4): 1063 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cambonie, C. Milesi, S. Fournier-Favre, F. Counil, S. Jaber, J.-C. Picaud, and S. Matecki Clinical Effects of Heliox Administration for Acute Bronchiolitis in Young Infants Chest, March 1, 2006; 129(3): 676 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Berkenbosch, R. E. Grueber, G. R. Graff, and J. D. Tobias Patterns of Helium-Oxygen (Heliox) Usage in the Critical Care Environment J Intensive Care Med, November 1, 2004; 19(6): 335 - 344. [Abstract] [PDF]
|
|
|
|
 |
|
 E. R. McFadden Jr. Acute Severe Asthma Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 740 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Kass Heliox Redux Chest, March 1, 2003; 123(3): 673 - 676. [Full Text] [PDF]
|
|
|
|
|
|
A. M.-H. Ho, A. Lee, M. K. Karmakar, P. W. Dion, D. C. Chung, and L. H. Contardi Heliox vs Air-Oxygen Mixtures for the Treatment of Patients With Acute Asthma: A Systematic Overview Chest, March 1, 2003; 123(3): 882 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Haynes, R. J. Sargent, and E. L. Sweeney Use of Heliox to Avoid Intubation in a Child With Acute Severe Asthma and Hypercapnia Am. J. Crit. Care., January 1, 2003; 12(1): 28 - 30. [Full Text] [PDF]
|
|
|
|
|
|
A. KATZ, M. A. GENTILE, D. M. CRAIG, G. QUICK, J. N. MELIONES, and I. M. CHEIFETZ Heliox Improves Gas Exchange during High-frequency Ventilation in a Pediatric Model of Acute Lung Injury Am. J. Respir. Crit. Care Med., July 15, 2001; 164(2): 260 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Werner Status Asthmaticus in Children : A Review Chest, June 1, 2001; 119(6): 1913 - 1929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. GOODE, J. B. FINK, R. DHAND, and M. J. TOBIN Improvement in Aerosol Delivery with Helium-Oxygen Mixtures during Mechanical Ventilation Am. J. Respir. Crit. Care Med., January 1, 2001; 163(1): 109 - 114. [Abstract] [Full Text]
|
|
|
|
|
|
C. E. R. Carter and J. E. Kass Heliox for Acute Severe Asthma Chest, April 1, 2000; 117(4): 1212 - 1213. [Full Text] [PDF]
|
|
|
|
|
|
J. E. Kass and C. A. Terregino The Effect of Heliox in Acute Severe Asthma: A Randomized Controlled Trial Chest, August 1, 1999; 116(2): 296 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Jantz and N. A. Collop Bronchodilator Aerosol Delivery in Mechanical Ventilation: Jantz MA, Collop NA Bronchodilator Aerosol Delivery in Mechanical Ventilation Intensive Care Med 1999,14 166-183 J Intensive Care Med, July 1, 1999; 14(4): 166 - 183. [PDF]
|
|
|
|
|
|
D. R. Hess, F. L. Acosta, R. H. Ritz, R. M. Kacmarek, and C. A. Camargo Jr The Effect of Heliox on Nebulizer Function Using a {beta}-Agonist Bronchodilator Chest, January 1, 1999; 115(1): 184 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Everett Alternatives to Standard Status Asthmaticus Therapy Journal of Pharmacy Practice, June 1, 1997; 10(3): 186 - 199. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
