Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Do, B.-K. Q.
Right arrow Articles by Habib, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Do, B.-K. Q.
Right arrow Articles by Habib, M. P.
(Chest. 1996;110:159-164.)
© 1996 American College of Chest Physicians

Exhaled Ethane and Antioxidant Vitamin Supplements in Active Smokers

Bao-Khanh Q. Do BS1; Harinder S. Garewal MD, PhD2; Neil C. Clements Jr MD, FCCP3; Yei-Mei Peng PhD4; and Michael P. Habib MD, FCCP3

1 From the Arizona Health Sciences Center, School of Medicine, Tucson
2 From the Department of Internal Medicine, Hematology Oncology Section, Veterans Affairs Medical Center; the Arizona Cancer Center, Arizona Health Sciences Center, Tucson
3 From the Department of Internal Medicine, Division of Respiratory Sciences, University of Arizona, and Pulmonary Section, Veterans Affairs Medical Center, Tucson
4 From the Arizona Cancer Center, Arizona Health Sciences Center, Tucson

To determine the effect of nutritional agents on lipid peroxidation, 10 smokers were given 6 mg beta carotene, 200 IU vitamin E, and 250 mg vitamin C 4 times daily for 3 weeks. Lipid peroxidation was assessed by measuring baseline and postsupplementation levels of exhaled ethane. There was a 29% decrease in mean (±SD) exhaled ethane (4.06±1.49 vs 2.90±1.29 pmol·kgminus1·minminus1), with individual levels decreasing in 8 of the 10 smokers (p<0.05, Wilcoxon sign rank test). Three nonsmokers had very low baseline levels of ethane that did not change with supplementation. Ethane production correlated with active (packs per day) and lifelong (pack-years) tobacco consumption. Also, a strong correlation was found between the decline in ethane output after micronutrient supplementation and the presupplement FEV1. Therefore, antioxidant vitamin supplementation resulted in attenuation of smoking-related lipid peroxidation, and the decreases in ethane production appears to be associated with preserved lung function.

Key Words: ascorbic acid • carotene • ethane • lipid peroxidation • smoking • vitamin E

Submitted on November 7, 1995
Accepted on January 18, 1996




This article has been cited by other articles:


Home page
 Eur Respir JHome page
I. Horvath, W. MacNee, F.J. Kelly, P.N.R. Dekhuijzen, M. Phillips, G. Doring, A.M.K. Choi, M. Yamaya, F.H. Bach, D. Willis, et al.
"Haemoxygenase-1 induction and exhaled markers of oxidative stress in lung diseases", summary of the ERS Research Seminar in Budapest, Hungary, September, 1999
Eur. Respir. J., August 1, 2001; 18(2): 420 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. A. KHARITONOV and P. J. BARNES
Exhaled Markers of Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1693 - 1722.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. B. Weinberg, B. S. VanderWerken, R. A. Anderson, J. E. Stegner, and M. J. Thomas
Pro-Oxidant Effect of Vitamin E in Cigarette Smokers Consuming a High Polyunsaturated Fat Diet
Arterioscler. Thromb. Vasc. Biol., June 1, 2001; 21(6): 1029 - 1033.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. A Riemersma, K. F Carruthers, R. A Elton, and K. A. Fox
Vitamin C and the risk of acute myocardial infarction
Am. J. Clinical Nutrition, May 1, 2000; 71(5): 1181 - 1186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. C Carr and B. Frei
Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans
Am. J. Clinical Nutrition, June 1, 1999; 69(6): 1086 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. P. Habib, L. J. Tank, L. C. Lane, and H. S. Garewal
Effect of Vitamin E on Exhaled Ethane in Cigarette Smokers
Chest, March 1, 1999; 115(3): 684 - 690.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the American College of Chest Physicians.