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(Chest. 1996;110:286-289.)
© 1996 American College of Chest Physicians

High-Altitude Pulmonary Edema With Primary Pulmonary Hypertension

Robert Naeije MD, PhD1; Daniel De Backer MD1; Jean-Luc Vachiéry MD2; and Paul De Vuyst MD, PhD3

1 From the Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
2 From the Department of Cardiology, Erasme University Hospital, Brussels, Belgium
3 From the Department of Pneumology, Erasme University Hospital, Brussels, Belgium

A 43-year-old woman had two episodes of lung edema at moderate altitudes. She had taken slimming pills containing fenfluramine hydrochloride and diethylpropion hydrochloride. At sea level, catheterization of the right side of the heart showed a mean pulmonary artery pressure of 16 mm Hg, which increased to 34 mm Hg with mild exercise in a supine position. An extensive workup failed to identify a cardiac or a pulmonary cause of pulmonary hypertension. This patient experienced mild primary pulmonary hypertension related to the intake of anorexigens, which was revealed by high-altitude pulmonary edema.

Key Words: anorexigen • high-altitude pulmonary edema • primary pulmonary hypertension

Submitted on November 16, 1995
Accepted on January 30, 1996




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Copyright © 1996 by the American College of Chest Physicians.