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(Chest. 1996;110:289-292.)
© 1996 American College of Chest Physicians

Pulmonary Infiltrates Following Administration of Paclitaxel

Ramesh K. Ramanathan MD1; Vundyala V. Reddy MD2; J. Michael Holbert MD1; and Chandra P. Belani MD1

1 From the University of Pittsburgh Cancer Institute and the University of Pittsburgh School of Medicine, Pittsburgh
2 From the Medical Oncology P.A., Macon, Ga.

The clinical spectrum of hypersensitivity reactions reported with paclitaxel has not included the occurrence of pulmonary infiltrates. This report describes three patients who developed transient pulmonary infiltrates after receiving paclitaxel. These infiltrates were noted 2 days to 2 weeks after administration of paclitaxel. The infiltrates resolved spontaneously in all the patients but one of them did receive steroid therapy. This syndrome of transient pulmonary infiltrates did not reoccur in the two patients who were rechallenged with paclitaxel. Physicians should be made aware of this unique occurrence during the course of treatment with paclitaxel.

Key Words: carboplatin • hypersensitivity reaction • nonsmall cell lung cancer • paclitaxel • pulmonary infiltrates

Submitted on July 17, 1995
Accepted on February 2, 1996




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