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1 From the Department of Diagnostic Radiology, Mayo Clinic and Mayo Foundation, Rochester, Minn
2 From the Department of Radiology, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada
3 From the Department of Radiology, Korea University Medical College, Seoul
4 From the Department of Radiology, Brompton Hospital, London, England
5 From the Department of Radiology, New York University Medical Center, Belleuve Hospital
Objective: To determine the outcome of areas of ground-glass attenuation and assess disease progression on serial high-resolution CT (HRCT) scans of patients with biopsy specimen-proved usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP).
Materials and methods: Twelve patients with biopsy specimen-proved UIP and 11 patients with biopsy specimen-proved DIP who had initial and follow-up HRCT scans (median interval, 10 months) were reviewed. Eleven patients with UIP and 11 with DIP received treatment between the initial and follow-up CT scans. The scans were evaluated for the presence and extent of ground-glass attenuation, irregular linear opacities and honeycombing, and overall extent of parenchymal involvement.
Results: On initial CT scans, all 12 patients with UIP had areas of ground-glass attenuation (mean±SD extent, 30±16%) and irregular lines (mean±SD extent, 17±7%) and 10 patients had honeycombing (mean±SD extent, 10±6%). All 11 patients with DIP had areas of ground-glass attenuation on initial HRCT scans (mean±SD extent, 51±26%), 5 patients had irregular linear opacities (mean±SD extent, 5±5%), and 1 patient had honeycombing. Nine of the 12 patients with UIP showed increase in the extent of ground-glass attenuation (n=6) or progression to irregular lines (n=2) or honeycombing (n=4) on follow-up as compared with only 2 patients with DIP who showed progression to irregular lines (n=l) or honeycombing (n=l) (p<0.01, 
2 test).
Conclusion: In patients with UIP, areas of ground-glass attenuation usually increase in extent or progress to fibrosis despite treatment. Areas of ground-glass attenuation in most patients with DIP remain stable or improve with treatment.
Key Words: computed tomography • desquamative interstitial pneumonia • disease progression • usual interstitial pneumonia
Submitted on August 1, 1995
Accepted on March 8, 1996
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